Masvidal (35-14) replaced Gilbert Burns on six days’ notice last July, facing Usman (18-1) after the ‘Nigerian Nightmare’s original challenger tested positive for coronavirus.
FOLLOW LIVE: UFC 261 – Latest Usman vs Masvidal updates
An intense weight cut for Masvidal gave way to a unanimous-decision loss, with the Floridian having claimed ever since that night in Abu Dhabi that a full camp would be enough to make amends for that defeat.
‘Gamebred’ will get the chance to prove it in his home state tonight, with 15,000 fans set to enter a full-capacity arena in Masvidal’s home state as the 36-year-old gets what will likely be his last crack at UFC gold.
Elsewhere on the card in Jacksonville, there are two women’s title fights, with Weili Zhang defending her strawweight belt against former divisional champion Rose Namajunas, and Valentina Shevchenko putting her flyweight strap on the line against Jessica Andrade – another former strawweight titleholder.
Here’s everything you need to know about UFC 261:
When is it?
The UFC 261 early prelims will begin at 11pm BST on Saturday night. The prelims will follow at 1am on Sunday morning, before the main card takes place at 3am.
How can I watch it?
The early prelims will stream live exclusively on UFC’s Fight Pass, with the prelims and main card airing live on BT Sport 1 in the UK and ESPN+ in the US.
What are the odds?
Kamaru Usman (2/9) vs Jorge Masvidal (7/2)
Weili Zhang (1/2) vs Rose Namajunas (17/10)
Valentina Shevchenko (2/9) vs Jessica Andrade (7/2)
Chris Weidman (4/5) vs Uriah Hall (1/1)
Anthony Smith (17/10) vs Jimmy Crute (1/2)
Kamaru Usman (C) vs Jorge Masvidal (welterweight)
Weili Zhang (C) vs Rose Namajunas (women’s strawweight)
Valentina Shevchenko (C) vs Jessica Andrade (women’s flyweight)
Chris Weidman vs Uriah Hall (middleweight)
Anthony Smith vs Jimmy Crute (light heavyweight)
Alex Oliveira vs Randy Brown (welterweight)
Dwight Grant vs Stefan Sekulic (welterweight)
Karl Roberson vs Brendan Allen (middleweight)
Patrick Sabatini vs Tristan Connelly (featherweight)
Danaa Batgerel vs Kevin Natividad (bantamweight)
Kazula Vargas vs Rongzhu (lightweight)
Aoriqileng vs Jeffrey Molina (flyweight)
Liang Na vs Ariane Carnelossi (women’s strawweight)