An Edinson Cavani strike and a Jesus Vallejo own goal helped United defeat Granada on Thursday and advance to the Europa League semi-finals.
The Red Devils have won four successive matches in all competitions, including a 3-1 win at Spurs in their last league match.
Meanwhile, Burnley will be hoping to stun Ole Gunnar Solskjaer’s team after back-to-back defeats by Southampton and Newcastle in the league.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4pm GMT at Old Trafford.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 3:30pm GMT.
What is the team news?
Marcus Rashford will be assessed ahead of kick-off as he battles an ankle issue, while Harry Maguire, Luke Shaw and Scott McTominay are all set to return after serving European suspensions. Eric Bailly may play, but Anthony Martial and Phil Jones are out.
For Burnley, Nick Pope may miss the trip to Old Trafford due to his shoulder injury, while Dwight McNeil took a knock in training. Ashley Barnes, Robbie Brady and Kevin Long are out.
Manchester United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Rashford, Fernandes, Pogba, Cavani
Burnley: Peacock-Farrell, Lowton, Tarkowski, Mee, Pieters, Gudmundsson, Brownhill, Westwood, McNeil, Wood, Vydra
Manchester United: 4/11
Manchester United are in dangerous form and I think they could get a few goals against Burnley, who have lost their way a little recently. 3-0 Manchester United.